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1

An Expedient and Practical Method for the Synthesis of a Diverse Series of Cyclopropane α-Amino Acids and Amines

Wurz, Ryan P., Charette, André B.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 172 KB

english, 2004

2

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors

Wurz, Ryan P., Sastri, Christine, D’Amico, Derin C., Herberich, Brad, M. Jackson, Claire L., Pettus, Liping H., Tasker, Andrew S., Wu, Bin, Guerrero, Nadia, Russell Lipford, J., Winston, Jeffrey T., Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

3

A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

Wurz, Ryan P., Dellamaggiore, Ken, Dou, Hannah, Javier, Noelle, Lo, Mei-Chu, McCarter, John D., Mohl, Dane, Sastri, Christine, Lipford, J. Russell, Cee, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 837 KB

english, 2017

4

Photoinduced, Copper-Catalyzed Decarboxylative C–N Coupling to Generate Protected Amines: An Alternative to the Curtius Rearrangement

Zhao, Wei, Wurz, Ryan P., Peters, Jonas C., Fu, Gregory C.

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 874 KB

english, 2017

5

Synthesis and Resolution of Planar-Chiral Derivatives of 4-(Dimethylamino)pyridine

Ryan P. Wurz, Elaine C. Lee, J. Craig Ruble, Gregory C. Fu

Journal:

Advanced Synthesis & Catalysis

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

6

ChemInform Abstract: Trifluoromethanesulfonyl Azide: A Powerful Reagent for the Preparation of α-Nitro-α-diazocarbonyl Derivatives.

Andre B. Charette, Ryan P. Wurz, Thierry Ollevier

Journal:

Year:

2001

File:

PDF, 31 KB

2001

7

Transition Metal-Catalyzed Cyclopropanation of Alkenes in Water: Catalyst Efficiency and in situ Generation of the Diazo Reagent.

Ryan P. Wurz, Andre B. Charette

Journal:

Year:

2003

File:

PDF, 244 KB

2003

8

Synthesis of α-Nitro-α-diazocarbonyl Derivatives and Their Applications in the Cyclopropanation of Alkenes and in O—H Insertion Reactions.

Andre B. Charette, Ryan P. Wurz, Thierry Ollevier

Journal:

Year:

2003

File:

PDF, 323 KB

2003

9

Hypervalent Iodine(III) Reagents as Safe Alternatives to α-Nitro-α-diazocarbonyls.

Ryan P. Wurz, Andre B. Charette

Journal:

Year:

2003

File:

PDF, 184 KB

2003

10

Trifluoromethanesulfonyl Azide: An Efficient Reagent for the Preparation of α-Cyano-α-diazo Carbonyls and an α-Sulfonyl-α-diazo Carbonyl.

Ryan P. Wurz, Wei Lin, Andre B. Charette

Journal:

Year:

2004

File:

PDF, 128 KB

2004

11

An Expedient and Practical Method for the Synthesis of a Diverse Series of Cyclopropane α-Amino Acids and Amines.

Ryan P. Wurz, Andre B. Charette

Journal:

Year:

2004

File:

PDF, 247 KB

2004

12

Doubly Activated Cyclopropanes as Synthetic Precursors for the Preparation of 4-Nitro- and 4-Cyano-dihydropyrroles and Pyrroles.

Ryan P. Wurz, Andre B. Charette

Journal:

Year:

2005

File:

PDF, 26 KB

2005

13

Catalytic Asymmetric Synthesis of Piperidine Derivatives Through the [4 + 2] Annulation of Imines with Allenes.

Ryan P. Wurz, Gregory C. Fu

Journal:

Year:

2006

File:

PDF, 35 KB

2006

14

Synthesis of α-Nitro-α-diazocarbonyl Derivatives and Their Applications in the Cyclopropanation of Alkenes and in OH Insertion Reactions

André B. Charette, Ryan P. Wurz, Thierry Ollevier

Journal:

Helvetica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 193 KB

english, 2002

15

Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Ryan P. Wurz, Liping H. Pettus, Shimin Xu, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, F

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 984 KB

english, 2009

16

Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

Ryan P. Wurz, Liping H. Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen J. McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, Faye Hsie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 523 KB

english, 2010

17

Trifluoromethanesulfonyl azide: an efficient reagent for the preparation of α-cyano-α-diazo carbonyls and an α-sulfonyl-α-diazo carbonyl

Ryan P. Wurz, Wei Lin, André B. Charette

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 106 KB

english, 2003

18

Progress towards asymmetric intermolecular and intramolecular cyclopropanations using α-nitro-α-diazo carbonyl substrates

André B. Charette, Ryan Wurz

Journal:

Journal of Molecular Catalysis A: Chemical

Year:

2003

Language:

english

File:

PDF, 139 KB

english, 2003

19

Discovery of Pyridazinopyridinones as Potent and Selective p38 Mitogen-Activated Protein Kinase Inhibitors

Wu, Bin, Wang, Hui-Ling, Pettus, Liping, Wurz, Ryan P., Doherty, Elizabeth M., Henkle, Bradley, McBride, Helen J., Saris, Christiaan J. M., Wong, Lu Min, Plant, Matthew H.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.25 MB

english, 2010

20

Identification of triazolopyridazinones as potent p38α inhibitors

Brad Herberich, Claire Jackson, Ryan P. Wurz, Liping H. Pettus, Lisa Sherman, Qiurong Liu, Bradley Henkle, Christiaan J.M. Saris, Lu Min Wong, Samer Chmait, Matthew R. Lee, Christopher Mohr, Faye Hsie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

21

Hypervalent Iodine(III) Reagents as Safe Alternatives to α-Nitro-α-diazocarbonyls

Wurz, Ryan P., Charette, André B.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 52 KB

english, 2003

22

Synthesis and structure–activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold

Ryan P. Wurz, Longbin Liu, Kevin Yang, Nobuko Nishimura, Yunxin Bo, Liping H. Pettus, Sean Caenepeel, Daniel J. Freeman, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Ling Wang, Nancy Zhang, Kr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 4.36 MB

english, 2012

23

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Yi-Hung Ou, Michael Torres, Rosalyn Ram, Etienne Formstecher, Christina Roland, Tzuling Cheng, Rolf Brekken, Ryan Wurz, Andrew Tasker, Tony Polverino, Seng-Lai Tan, Michael A. White

Journal:

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

24

Catalytic Asymmetric Synthesis of Piperidine Derivatives through the [4 + 2] Annulation of Imines with Allenes

Wurz, Ryan P., Fu, Gregory C.

Journal:

Journal of the American Chemical Society

Year:

2005

Language:

english

File:

PDF, 53 KB

english, 2005

25

Chiral Dialkylaminopyridine Catalysts in Asymmetric Synthesis

Journal:

Chemical Reviews

Year:

2007

Language:

english

File:

PDF, 781 KB

english, 2007

26

Transition Metal-Catalyzed Cyclopropanation of Alkenes in Water: Catalyst Efficiency and in Situ Generation of the Diazo Reagent

Wurz, Ryan P., Charette, André B.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 53 KB

english, 2002

27

Formal Synthesis of Belactosin A and Hormaomycin via a Diastereoselective Intramolecular Cyclopropanation of an α-Nitro Diazoester

Vanier, Sébastien F., Larouche, Guillaume, Wurz, Ryan P., Charette, André B.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 334 KB

english, 2010

28

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold #

Herberich, Brad, Cao, Guo-Qiang, Chakrabarti, Partha P., Falsey, James R., Pettus, Liping, Rzasa, Robert M., Reed, Anthony B., Reichelt, Andreas, Sham, Kelvin, Thaman, Maya, Wurz, Ryan P., Xu, Shimin,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 691 KB

english, 2008

29

Pyridin-2-one Synthesis Using Ester Enolates and Aryl Aminoaldehydes and Ketones

Apsunde, Tushar, Wurz, Ryan P.

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 763 KB

english, 2014

30

Trifluoromethanesulfonyl Azide: A Powerful Reagent for the Preparation of α-Nitro-α-diazocarbonyl Derivatives

Charette, André B., Wurz, Ryan P., Ollevier, Thierry

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 85 KB

english, 2000

31

Doubly Activated Cyclopropanes as Synthetic Precursors for the Preparation of 4-Nitro- and 4-Cyano-dihydropyrroles and Pyrroles

Wurz, Ryan P., Charette, André B.

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 77 KB

english, 2005

32

η 1 - and η 5 -Indenyl and Cyclopentadienyl Tri -tert -Butylphosphoraneiminatotitanium Complexes

Guérin, Frédéric, Beddie, Chad L., Stephan, Douglas W., Spence, Rupert E. v. H., Wurz, Ryan

Journal:

Organometallics

Year:

2001

Language:

english

File:

PDF, 86 KB

english, 2001

33

Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase ⊥ ⊥ Atomic coordinates and structure factors for crystal structure of compound 3d with p38α can be accessed using PDB code 3LHJ.

Pettus, Liping H., Wurz, Ryan P., Xu, Shimin, Herberich, Brad, Henkle, Bradley, Liu, Qiurong, McBride, Helen J., Mu, Sharon, Plant, Matthew H., Saris, Christiaan J. M., Sherman, Lisa, Wong, Lu Min, Ch

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.14 MB

english, 2010

34

3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase †

Pettus, Liping H., Xu, Shimin, Cao, Guo-Qiang, Chakrabarti, Partha P., Rzasa, Robert M., Sham, Kelvin, Wurz, Ryan P., Zhang, Dawei, Middleton, Scott, Henkle, Bradley, Plant, Matthew H., Saris, Christi

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 686 KB

english, 2008

35

Encyclopedia of Reagents for Organic Synthesis || Methyl Nitroacetate

Year:

2001

Language:

english

File:

PDF, 74 KB

english, 2001

36

Phosphoinositide-3-kinase inhibitors: Evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511

Lanman, Brian A., Reed, Anthony B., Cee, Victor J., Hong, Fang-Tsao, Pettus, Liping H., Wurz, Ryan P., Andrews, Kristin L., Jiang, Jian, McCarter, John D., Mullady, Erin L., San Miguel, Tisha, Subrama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.26 MB

english, 2014

37

ChemInform Abstract: Pyridin-2-one Synthesis Using Ester Enolates and Aryl Aminoaldehydes and Ketones.

Apsunde, Tushar, Wurz, Ryan P.

Journal:

Year:

2014

File:

PDF, 21 KB

2014

38

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors

Wurz, Ryan P., Pettus, Liping H., Jackson, Claire, Wu, Bin, Wang, Hui-Ling, Herberich, Brad, Cee, Victor, Lanman, Brian A., Reed, Anthony B., Chavez, Frank, Nixey, Thomas, Laszlo, Jimmy, Wang, Paul, N

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 934 KB

english, 2015

39

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors

Wu, Bin, Wang, Hui-Ling, Cee, Victor J., Lanman, Brian A., Nixey, Thomas, Pettus, Liping, Reed, Anthony B., Wurz, Ryan P., Guerrero, Nadia, Sastri, Christine, Winston, Jeff, Lipford, J. Russell, Lee,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 616 KB

english, 2015

40

Encyclopedia of Reagents for Organic Synthesis || Rhodium Tetrakis[tricyclo[3.3.1.13,7]decane-1-carboxylate]

Year:

2001

Language:

english

File:

PDF, 100 KB

english, 2001

41

Oxopyrido[2,3- d ]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

Wurz, Ryan P., Pettus, Liping H., Ashton, Kate, Brown, James, Chen, Jian Jeffrey, Herberich, Brad, Hong, Fang-Tsao, Hu-Harrington, Essa, Nguyen, Tom, St. Jean, David J., Tadesse, Seifu, Bauer, David,

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 311 KB

english, 2015

42

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors

Cee, Victor J., Chavez, Frank, Herberich, Bradley, Lanman, Brian A., Pettus, Liping H., Reed, Anthony B., Wu, Bin, Wurz, Ryan P., Andrews, Kristin L., Chen, Jie, Hickman, Dean, Laszlo, Jimmy, Lee, Mat

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

43

Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors

Wurz, Ryan P., Cee, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 540 KB

english, 2018

44

Discovery of N -(1-Acryloylazetidin-3-yl)-2-(1 H -indol-1-yl)acetamides as Covalent Inhibitors of KRAS G12C

Shin, Youngsook, Jeong, Joon Won, Wurz, Ryan P., Achanta, Pragathi, Arvedson, Tara, Bartberger, Michael D., Campuzano, Iain D. G., Fucini, Ray, Hansen, Stig K., Ingersoll, John, Iwig, Jeffrey S., Lipf

Journal:

ACS Medicinal Chemistry Letters

Year:

2019

File:

PDF, 4.11 MB

2019

45

Discovery of [1,2,4]Triazolo[1,5- a ]pyridine Derivatives as Potent and Orally Bioavailable RORÎ³t Inverse Agonists

Nakajima, Ryota, Oono, Hiroyuki, Sugiyama, Sakae, Matsueda, Yohei, Ida, Tomohide, Kakuda, Shinji, Hirata, Jun, Baba, Atsushi, Makino, Akito, Matsuyama, Ryo, White, Ryan D, Wurz, Ryan P., Shin, Youngso

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

Language:

english

File:

PDF, 406 KB

english, 2020

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